The BioCollector™ is the industry’s most effective and efficient stool sample collection system for whole stool. Patented patient (donor/user) friendly operation collects whole stool specimens.
The BioCollector™ was specifically designed to provide samples for consistent, standardized, replicable and scalable research.
Key Features :
Easy at home collection of whole stool, improves participant compliance
Maintains 4° C to 48 hours in shipping
Suitable for collecting stools for genomic, metabolomic, proteomic, and strain isolations
Key advantages of the full spectrum sample :
Multiple identical aliquots for expanded and reproducible research
Provides an economically advantageous solution for multiple studies
Whole stool eliminates the bias associated with subsampling of partial stool.
For the Donor & Research Facility
Whole stool collection enables homogenized, replicates for repeated and expanded research
Eliminates “sampling” bias
Simple for the participant/patient, no scooping or handling the stool prior to shipping
While microbiome research continues to grow exponentially, much of the research today has not used controls such as reference samples or mock communities to standardize data. This has led to a stochastic, non-standardized approaches where data are not readily comparable across published research and results may be impacted by bias is various steps in the process.
The BioCollective, working with DNANexus and Janssen Pharmaceuticals, developed a homogenized whole stool fecal reference sample for their Mosaic Standards Challenge to identify many of the issues of bias that can be introduced in the research.
Leveraging our expertise in whole stool collection, homogenization and processing we are working with NIST to improve industry standards, The BioCollective has developed a line of products to serve as reference materials for research.
These products include:
Whole stool fecal reference material, TBC WSFR™
Whole stool certified metabolomics reference TBC CMR™
Mock Reference Material TBC MRM™
Cohort Specific Reference Material TBC CoHo™
Microbiome standards and reference materials will enable federal, academic, and industry labs to reliably reproduce and advance each other's results; thereby enabling the commercial and clinical translation of microbiome science.
“One accurate measurement is worth a thousand expert opinions”
Grace Murray Hopper
Rear Admiral US NAVY
Available in different matrices - DNA/RNA stabilization, lyophilized, glycerol, saline
Transport and store at ambient temperature
Barcoded for full traceability
Standard sample tubes ideal for manual or high-throughput, automated processing
Microbial diversity fully representative of the gut microbiome
More representative than “mock” communities in aqueous suspensions
Broad distribution of Taxa
Validated method of fecal homogenization and sample preparation to achieve a consistent microbial profile
WGS and 16S reference data from multiple pipelines/kits - Zymo, DNAgenotek, PacBio, IonTorrent
Proposed Composition Health Human Stool Matrix
|Component||Percent of Total|
The BioCRM Partnerships
TBC Sample Bank
The BioCollective Sample Bank contains an array of specimens ranging from subjects aged 1 to 102, with a broad diversity of health & lifestyles with metadata for age, sex, medications, diet and more.
Additionally, samples are searchable across data categories including the presence or absence of specific organisms.
Homogenized replicates - allow for work to be repeated and expanded in multiple pipelines from the same sample
Multiple aliquots for many uses - genomics, metabolomics, proteomics, isolation and culturing, animal models, etc.
Standard method of collection using the BioCollector™ and validated collection process to maintain 4° C temp during transport
Validated for isolation and culturing of anaerobes
Broad population samples available
50% healthy, as well as cohorts in Parkinson’s, IBD, Crohn’s, Autism, Cancer, Thyroid disease, and more.
Metadata - age, sex, medications, diet
Metagenomic data available, capability to search by organism
1 g neat
.2 g neat
1.5 ml cryopreserved in PBS Glycerol